White Sox manager Tony La Russa says Yermín Mercedes made a “big mistake” when he crushed a 3-0 pitch from infielder Willians Astudillo for a solo homer in the ninth inning of Monday night’s 16-4 victory over the Minnesota Twins. The 76-year-old Hall of Fame manager said he was yelling for Mercedes to take. Instead, the rookie drove the 47-mph eephus pitch deep to center for his sixth homer — and touched off yet another debate about baseball’s unwritten rules. On Tuesday night, Twins reliever Tyler Duffey threw a pitch behind Mercedes’ legs and was ejected, as was Twins manager Rocco Baldelli.