How soon vaccines expire is a critical question as the Biden administration prepares to send tens of millions of unused COVID-19 doses abroad to help curb the pandemic. Many drugs and vaccines can last for years if stored properly, but all can eventually lose their effectiveness much like how food can degrade in a pantry. Like many perishable items, COVID-19 vaccines remain stable longer at lower temperatures. The vaccines authorized in the U.S., made by Pfizer, Moderna and Johnson & Johnson, can last for up to about six months from the time of manufacture, depending on how they’re stored.